After my Website was hacked, I researched on the Internet all I could about the .htaccess file. Here is a portion of my file. The "deny from can contain multiple ip addresses and you can block whole subnets by entering as an example 194.874. makeing sure you have the trailing period. As far as the bad user agents, they are available on the Internet, all you have to do is search for them and add them into the correct section. Since I implemented my .htaccess file I have not had any problems at all!
# Lets deny some users
# deny from xx.xxx.xxx.xxx
# Use Options
Options +FollowSymLinks
# mod_rewrite in use
RewriteEngine On
# Uncomment following line if your webserver’s URL
# is not directly related to physical file paths.
#RewriteBase /
#RewriteCond %{HTTP_HOST} ^corephp\.com
#RewriteRule ^(.*)$
http://www.corephp.com/$1 [R=permanent,L]
#Redirect moved pages
#Redirect 301 /old-link.html
http://www.corephp.com/new-link.html#Rewrites
#RedirectMatch ^/somedir(/)?$
http://www.corephp.com/index.php?option=com_somecomponentServerSignature Off
RewriteCond %{REQUEST_METHOD} ^(HEAD|TRACE|DELETE|TRACK) [NC,OR]
RewriteCond %{THE_REQUEST} ^.*(\\r|\\n|%0A|%0D).* [NC,OR]
RewriteCond %{HTTP_REFERER} ^(.*)(<|>|’|%0A|%0D|%27|%3C|%3E|%00).* [NC,OR]
RewriteCond %{HTTP_COOKIE} ^.*(<|>|’|%0A|%0D|%27|%3C|%3E|%00).* [NC,OR]
#RewriteCond %{REQUEST_URI} ^/(,|;|:|<|>|'>|'<|/|\\\.\.\\).{0,9999}.* [NC,OR]
RewriteCond %{HTTP_USER_AGENT} ^$ [OR]
RewriteCond %{HTTP_USER_AGENT} ^(java|curl|wget).* [NC,OR]
RewriteCond %{HTTP_USER_AGENT} ^.*(winhttp|HTTrack|clshttp|archiver|loader|email|harvest|extract|grab|miner).* [NC,OR]
RewriteCond %{HTTP_USER_AGENT} ^.*(libwww-perl|curl|wget|python|nikto|scan).* [NC,OR]
RewriteCond %{HTTP_USER_AGENT} ^.*(<|>|’|%0A|%0D|%27|%3C|%3E|%00).* [NC,OR]
RewriteCond %{QUERY_STRING} ^.*(;|<|>|’|”|\)|%0A|%0D|%22|%27|%3C|%3E|%00).*(/\*|union|select|insert|cast|set|declare|drop|update|md5|benchmark).* [NC,OR]
RewriteCond %{QUERY_STRING} ^.*(localhost|loopback|127\.0\.0\.1).* [NC,OR]
RewriteCond %{QUERY_STRING} ^.*\.[A-Za-z0-9].* [NC,OR]
RewriteCond %{QUERY_STRING} ^.*(<|>|’|%0A|%0D|%27|%3C|%3E|%00).* [NC]
########## Begin - Rewrite rules to block out some common exploits
## If you experience problems on your site block out the operations listed below
## This attempts to block the most common type of exploit `attempts` to Joomla!
## Block out any script trying to set a mosConfig value through the URL
RewriteCond %{QUERY_STRING} mosConfig_[a-zA-Z_]{1,21}(=|\%3D) [OR]
# Block out any script trying to base64_encode crap to send via URL
RewriteCond %{QUERY_STRING} base64_encode.*\(.*\) [OR]
# Block out any script that includes a <script> tag in URL
RewriteCond %{QUERY_STRING} (\<|%3C).*script.*(\>|%3E) [NC,OR]
# Block out any script trying to set a PHP GLOBALS variable via URL
RewriteCond %{QUERY_STRING} GLOBALS(=|\[|\%[0-9A-Z]{0,2}) [OR]
# Block out any script trying to modify a _REQUEST variable via URL
RewriteCond %{QUERY_STRING} _REQUEST(=|\[|\%[0-9A-Z]{0,2})
# Send all blocked request to homepage with 403 Forbidden error!
RewriteRule ^(.*)$ index.php [F,L]
########### End - Rewrite rules to block out some common exploits
########## Begin - Joomla! core SEF Section#
#RewriteCond %{REQUEST_FILENAME} !-f
#RewriteCond %{REQUEST_FILENAME} !-d
#RewriteCond %{REQUEST_URI} !^/index.php
#RewriteCond %{REQUEST_URI} (/|\.php|\.html|\.htm|\.feed|\.pdf|\.raw|/[^.]*)$ [NC]
#RewriteRule (.*) index.php
#RewriteRule .* - [E=HTTP_AUTHORIZATION:%{HTTP:Authorization},L]
########### End - Joomla! core SEF Section
########## Block bad user agents
RewriteCond %{HTTP_USER_AGENT} ^BlackWidow [OR]
RewriteCond %{HTTP_USER_AGENT} ^Bot\ mailto:craftbot@yahoo.com [OR]
RewriteCond %{HTTP_USER_AGENT} ^ChinaClaw [OR]
RewriteCond %{HTTP_USER_AGENT} ^Custo [OR]
RewriteCond %{HTTP_USER_AGENT} ^DISCo [OR]
RewriteCond %{HTTP_USER_AGENT} ^Download\ Demon [OR]
RewriteCond %{HTTP_USER_AGENT} ^eCatch [OR]
RewriteCond %{HTTP_USER_AGENT} ^EirGrabber [OR]
RewriteCond %{HTTP_USER_AGENT} ^EmailSiphon [OR]
RewriteCond %{HTTP_USER_AGENT} ^EmailWolf [OR]
RewriteCond %{HTTP_USER_AGENT} ^Express\ WebPictures [OR]
RewriteCond %{HTTP_USER_AGENT} ^ExtractorPro [OR]
RewriteCond %{HTTP_USER_AGENT} ^EyeNetIE [OR]
RewriteCond %{HTTP_user_AGENT} (copier¦collect¦download¦express¦extract¦grab¦mail¦mass¦offline|attach¦copy¦entry¦extract¦Ninja¦Stripper¦Sucker¦Whacker) [NC]
Maybe the Moderator will be kind enough to sticky this post

Cheers!
etech97:)