Hi there,

I don't know if I am posting at the right place... but still...

Ok here is the problem... I have a news site running on WordPress and I regularly post 3-4 news in the same. It was all working fine with plugins and everything. But from the past one week it is having problems.
As soon as i publish any post my sites homepage goes down. All pages work except for the homepage. 
I first thought it was due to some plugins, and i deactivated few and the blog was running perfectly... Now again the same thing happens.. Whenever I post a new topic my homepage goes down... and then randomly I deactivate some plugin and the blog starts again...
This is happening every single day...

Now I don't thing this is due to some plugin because I have already deactivated almost all the plugins...

What might be causing my sites homepage to go down everytime... 

Thanks for the prompt reply...
Here is the list..

Activated
Akismet
Easy Contact
Flexi Quote Rotator
Google Analytics for WordPress
News-Ticker
OptinPop
Page Links To
Platinum SEO Pack
WP-PageNavi
WP-Polls
WP-PostRatings
WP-PostViews
WP-Print
WP-Table Reloaded
Wp2BB


Deactivated
WP Greet Box
WP-ContactForm
Subscribe To Comments
Dagon Design Form Mailer

Ya I deactivated those plugins plus removed lots many more.. which were not needed.
There is not error on the site / homepage.

I will try the solution you have suggested...

Activating all the plugins first.. and then trying deactivating individual plugins and checking... 

Well sounds like you found the plugin culprit, which is a good thing.  Might try keeping it disabled if you can for a day or so, see if you notice the problem come back - and/or make sure you are using the most latest version of the plugin (1.4.1).

if one plugin is directly tied to the problem.  So activate them all, then publish, then see if your site dies.  If it does, remove one, try to post, and see if fixes it.  Lot of manual labor, but hunting down a cause of an issue like this always is.